How Big of a Deal is this Cancer Vaccine?

Moderna and Merck announced that they have completed a Phase 3 trial for a vaccine that significantly improves outcomes for people with melanoma (the most deadly form of skin cancer.) This is very exciting...but /how/ exciting is it? And could it mean not just a new cancer therapy but a whole new /class/ of cancer therapies? I think it could very well be both. SOURCES THE PRESS RELEASE https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/ Melanoma staging and mutations https://www.cancer.gov/types/skin/patient/melanoma-treatment-pdq https://pmc.ncbi.nlm.nih.gov/articles/PMC4580370/ Keytruda and checkpoint inhibitors https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/checkpoint-inhibitors https://www.cancer.gov/about-cancer/treatment/drugs/pembrolizumab immune-mediated colitis https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 MHC I https://www.ncbi.nlm.nih.gov/books/NBK459467/ How the therapy works https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/ https://doi.org/10.1200/JCO-26-00835 Clinical Trial for just the Covid vaccine plus keytruda https://clinicaltrials.gov/study/NCT07597070?utm_source=chatgpt.com The paper that identified the weird effect with covid vaccines and keytruda https://www.nature.com/articles/s41586-025-09655-y?utm_id=97760_v0_s00_e0_tv4